Many facets of the immune system can be manipulated to combat cancer, including macrophages, an immune cell subset that is commonly associated with aiding tumor growth. In a new preclinical study in Cancer Discovery,, researchers from the Abramson Cancer Center (ACC) at the University of Pennsylvania have uncovered the poorly understood mechanics of how macrophages can be "re-educated" by an experimental immune therapy to help tear down the scaffolding that surrounds and protects pancreas cancer from chemotherapy.
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