Glucose-guzzling immune cells may drive coronary artery disease, Stanford...
Hyper-aggressive immune cells parked in arterial plaque and bingeing on glucose appear to be major drivers of coronary artery disease, Stanford University School of Medicine investigators have found.
View ArticleImmune therapy breaks down wall around pancreatic tumors for chemo to attack
Many facets of the immune system can be manipulated to combat cancer, including macrophages, an immune cell subset that is commonly associated with aiding tumor growth. In a new preclinical study in...
View ArticleResearchers prove HIV targets tissue macrophages
Investigators in the Division of Infectious Diseases at the University of North Carolina School of Medicine have clearly demonstrated that HIV infects and reproduces in macrophages, large white blood...
View ArticleHIV-infected young males have higher rates of bone loss than females
Accumulating evidence suggests that rates of low bone mass are greater in HIV-infected males than in females. Researchers led by Grace Aldrovandi, MD, chief of the Division of Infectious Diseases at...
View ArticleSaturated fat 'short-circuits' immune cells to trigger inflammation
Research by UC San Francisco scientists has opened up a surprising new avenue for potential therapies to reduce the risk of type 2 diabetes and other metabolic disorders that are associated with...
View ArticleImmunoproteasome inhibits healing function of macrophages
Scientists of Helmholtz Zentrum München, a partner in the German Center for Lung Research (DZL), have observed that the immunoproteasome inhibits the repair function of alveolar macrophages. This opens...
View Article'Clogged-up' immune cells help explain smoking risk for TB
Smoking increases an individual's risk of developing tuberculosis (TB) - and makes the infection worse - because it causes vital immune cells to become clogged up, slowing their movement and impeding...
View ArticleMacrophages surrounding lymph nodes block the progression of melanoma, other...
Researchers at Massachusetts General Hospital (MGH) have identified a type of immune cell that appears to block the progress of melanoma and other cancers in animal models. These subcapsular sinus...
View ArticleScientists reveal how osteopontin ablation ameliorates muscular dystrophy
Removing an immunomodulatory protein called osteopontin improves the symptoms of mice with muscular dystrophy by changing the type of macrophages acting on damaged muscle tissue, according to a paper...
View ArticleTuberculosis bacteria build 'edible' havens in immune cells
Bacteria that cause tuberculosis trick immune cells meant to destroy them into hiding and feeding them instead. This is the result of a study led by researchers from NYU Langone Medical Center and...
View ArticleResearch paves the way for monocyte-based cell therapy
Researchers from VIB-UGent reveal that adult circulating monocytes that get access to the macrophage niche in the liver or the lung can acquire identical tissue-specific macrophage functions and...
View ArticleImmune cells in organ cavities play essential role in fast tissue repair
While scientists have known for many years that there are cells living in the cavities surrounding various organs such as the heart, lung and liver, their function has remained unknown. A recent...
View ArticleWatch immune cells 'glue' broken blood vessels back together
As we age, tiny blood vessels in the brain stiffen and sometimes rupture, causing "microbleeds." This damage has been associated with neurodegenerative diseases and cognitive decline, but whether the...
View ArticleMacrophage population activates repair in murine heart attack model
Following a heart attack, successful repair of damaged tissue can prevent cardiac rupture and other adverse outcomes. The ability to repair myocardial tissue depends on the activation of fibroblasts,...
View ArticleFinely tuned electrical fields give wound healing a jolt
A new research report appearing in the June 2016 issue of the Journal of Leukocyte Biology, opens up the possibility that small electrical currents might activate certain immune cells to jumpstart or...
View ArticleResearchers find potential key to preventing heart attacks, strokes in older...
As men and women grow older, their chances for coronary heart disease also increase. Atherosclerosis is a condition in which plaque builds up inside the arteries, which can lead to serious problems,...
View ArticleNatural metabolite can suppress inflammation
An international group of scientists from the U.S., Canada, Germany and Russia has revealed a naturally occurring organic compound that can suppress the pro-inflammatory activity of macrophages. The...
View ArticleAnti-tumor antibodies could counter atherosclerosis, study finds
Investigators at the Stanford University School of Medicine have learned the signal that tumor cells display on their surfaces to protect themselves from being devoured by the immune system also plays...
View ArticleResearchers reveal how an inflammatory response to ceramic scaffolds promotes...
In their mission to design new biomaterials that promote tissue regeneration, Drexel University researchers have identified how inflammation, when precisely controlled, is crucial to bone repair.
View ArticleHeart-resident macrophages call in neutrophils following ischemic injury
Tissue injury, such as occurs in response to a lack of oxygen, promotes an influx of immune cells to the site of damage. After an ischemic injury to the heart, such as occurs after a heart attack or...
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